Out of the box, IE6's toolbar layout is not terribly efficient. Have a look:

There's some space wasted to the right of the menu bar, unnecessary buttons on the toolbar, and no way to access frequently used web sites. IE7 is a lot better, but luckily it's pretty easy to customize the layout. My preference is something like this:

If you're not sure how to make these changes, here are some simple steps:

1) First, right click on the toolbar and unlock it:

2) Next drag the address bar right next to the menu. Feel free to hide the Help menu.

3) Right click on the icons toolbar and select Customize. Remove unnecessary buttons, text labels, and select an icon size you're comfortable with.

4) Next, drag the Links bar next to the icons toolbar. Customize these links with the web sites you frequent the most. Remember you can add folders here too.

5) Finally, lock the taskbar. That's it.